Hypothalamic control of the anterior pituitary. An experimental-morphological study (Budapest, 1962)
J. Szentágothai, В. Flerkó В. Mess and В. Halász HYPOTHALAMIC CONTROL OF THE ANTERIOR PITUITARY This monograph summarizes the results of ten years’ teamwork on neurohormonal regulation mechanisms, conducted in the Anatomy Department of the Pécs University. It gives a detailed anatomical and histological analysis of the hypothalamo-hypophyseal complex, with due regard to the interests of the experimenter (stereotactic co-ordinates, Golgi cytoarchitecture, synaptology, hypothalamic pathways, blood circulation and innervation of the pituitary gland). A vast experimental material concerning hypothalamic control of thyrotrophic, adrenocorticotrophic and gonadotrophic functions is presented It is attempted to analize endocrine mechanisms chiefly from the viewpoint of feedback control. Several new technical approaches to this field are made, including the extensive use of intrahypothalamic and intrahypophyseal transplantations of endocrine tissues and of caryometric methods. The monograph is of peculiar interest for the experimental and clinical endocrinologist. The thorough treatment of the functional anatomy of the hypothalamus makes it a useful aid for the neuroanatomist, the neurophysiologist and the clinical neurologist. Owing to the daring and provocative raising of new concepts, such as direct internal feedback mechanisms, and several rather unusual histological and experimental modes of approach, the volume is a stimulating reading for everybody interested in experimental medicine and biology.