László Ferenc A.: Renal cortical necrosis. Experimental induction by hormones (Budapest, 1981)

RENAL CORTICAL NECROSIS EXPERIMENTAL INDUCTION BY HORMONES E A. LÁSZLÓ The author describes experimental data which demon­strate the importance of hormones in the development of this extremely serious disease. The first chapter presents a compact survey of the literature on bilateral renal cortical necrosis. In the second chapter an account is given of the methods employed in the complex investigation of the problem: fluorescence and electron­­microscopy; circulation examinations with an isotopic indicator and with a serioangiographic method; in vitro and in vivo measurements of the oxygen uptake of the kidney. The subsequent chapters contain the results of the experimental work: in rats bilateral renal cortical necrosis can be induced by the administration of vasopressin after oestrogen pretreatment. The author contributes new data towards an under­standing of the pathomechanism of renal cortical ne­crosis, which may be of great importance in the pre­vention of the disease. The work will be of interest to specialists in theoretical and clinical medicine, endo­crinology, nephrology, pathology, obstetrics, gynae­cology and urology. Akadémiai Kiadó Budapest

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